Leishmania amazonensis Amastigotes Highly Express a Tryparedoxin Peroxidase Isoform That Increases Parasite Resistance to Macrophage Antimicrobial Defenses and Fosters Parasite Virulence
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Leishmania amazonensis Amastigotes Highly Express a Tryparedoxin Peroxidase Isoform That Increases Parasite Resistance to Macrophage Antimicrobial Defenses and Fosters Parasite Virulence
Professional phagocytes generate a myriad of antimicrobial molecules to kill invading microorganisms, of which nitrogen oxides are integral in controlling the obligate intracellular pathogen Leishmania. Although reactive nitrogen species produced by the inducible nitric oxide synthase (iNOS) can promote the clearance of intracellular parasites, some Leishmania species/stages are relatively resi...
متن کاملA Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes
Infection of mammalian hosts with Leishmania amazonensis depends on the remarkable ability of these parasites to replicate within macrophage phagolysosomes. A critical adaptation for survival in this harsh environment is an efficient mechanism for gaining access to iron. In this study, we identify and characterize LIT1, a novel L. amazonensis membrane protein with extensive similarity to IRT1, ...
متن کاملThe Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis ...
متن کاملLeishmania--a parasitized parasite.
Alerting the host to an infection is a critical step in the development of an immune response, and identifying the pathogen-specific molecules that sound the alarm has preoccupied immunologists for more than 20 years. A recent study by Ives et al.1 shows that infection of the protozoan parasite leishmania with an endogenous virus augments the immune response — which perhaps is not such a good t...
متن کاملParasite Virulence
Some parasites exact a terrible price from their hosts, causing severe pathology and reducing the host’s fitness, whereas other parasites are essentially benign. Several kinds of comparisons highlight this observation. Least interesting are comparisons of parasites with very different life histories or types of host tissues invaded (compare human immunodeficiency virus (HIV) and rhinovirus infe...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2014
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0003000